Antioxidant-induced changes in oxidized DNA
نویسندگان
چکیده
منابع مشابه
Antioxidant-induced changes in oxidized DNA.
N-acetylcysteine (NAC), a strong antioxidant, has antigenotoxic and anticarcinogenic properties currently being investigated in clinical trials. NAC detoxifies free radicals (e.g., the hydroxyl radical,.OH) that cause DNA changes implicated in disease (e.g., cancer). The.OH reacts with purines to form mutagenic 8-hydroxypurine (8-OH) and putatively nonmutagenic formamidopyrimidine (Fapy) lesion...
متن کاملChanges in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells.
Transgenic mice overexpressing Cu/Zn superoxide dismutase (hSod1Tg(+/0)) or catalase (hCatTg(+/0)) and knockout mice underexpressing manganese superoxide dismutase (Sod2(+/)(-)) or glutathione peroxidase-1 (Gpx1(-/-)) were used to study the effect of antioxidant enzymes on cell-mediated low density lipoprotein (LDL) oxidation and oxidized LDL (oxLDL)-induced apoptosis. Incubation of LDL with mo...
متن کاملMethyl Jasmonate-Induced Changes in Non- and Antioxidant-Enzymatic Defense in Peppermint (Mentha piperita)
Peppermint (Mentha piperita L.), a herbaceous and perennial species whichis produced mainly for the medicine and food. The peppermint plants were initiated from 10 cm-long rhizome cuttings followed by transferring into pots. The 48 h-treated plants with methyl jasmonate (MJ) concentrations (0, 0.1, 0.5 mM) were assessed for their total soluble proteins, malondialdehyde (MDA), chlorophylls a, b ...
متن کاملSalt-induced Changes of Antioxidant Enzymes Activity in Winter Canola (Brassica napus) Cultivars in Growth Chamber
The effect of salinity was assessed on the activity of some major antioxidant enzymes i.e., superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), in the seedlings’ roots or shoots of three winter canola (Brassica napus L.) cultivars, Colvert (tolerant), Symbol (semi tolerant) and Agat (susceptible). Seedlings were treated with 0 (control), 50, 100 and 150 mM NaCl for 24 h in hydropoic c...
متن کاملDifferentiation-induced Changes in Antioxidant Capacity and Antioxidant Response in Sh-sy5y Cells: Role of Nrf2
.................................................................................................ii ACKNOWLEDGEMENTS................................................................................iii TABLE OF CONTENTS..................................................................................iv LIST OF FIGURES...................................................................................
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.082111199